Is CBG oil good for heart?
Heart disease remains the leading cause of death worldwide. Finding natural ways to support heart health is therefore a top priority. This has many people wondering: could CBG oil possibly be good for the heart?
- Why Heart Health Matters
- CBG’s Potential Cardiovascular Benefits and Effects
- CBG’s Vascular Mechanisms of Action
- Early Research Into CBG for Heart Conditions
- Other Positive CBG Effects Relevant to Heart Health
- Optimal Types of CBG Products for Heart Health Support
- Is CBG Safe for Heart Health? Possible Side Effects and Considerations
- Is CBG oil good for heart? Conclusion
- Frequently Asked Questions About CBG Oil for Heart Health
- Resources used to write this article
Cannabigerol (CBG) is an intriguing phytocannabinoid found in hemp and cannabis plants. Research into CBG is still in early stages. But promising results from preclinical studies have raised hope that CBG could become a future option for supporting heart function and reducing cardiovascular disease risk factors.
Let’s take a closer look at what science says so far regarding CBG oil and heart health.
Why Heart Health Matters
Before examining CBG’s specific cardiovascular effects, it helps to understand why maintaining a healthy heart is so vital for overall wellbeing. Here’s a quick overview of why heart health should be a priority:
- Heart disease is the #1 cause of death globally, responsible for over 17 million deaths per year.
- Heart disease refers to conditions affecting heart structure, function, rhythm, and blood flow. Types include coronary artery disease, arrhythmias, and heart failure.
- Risk factors like obesity, diabetes, high cholesterol, hypertension, smoking, and stress all raise chances of developing heart disease.
- Heart disease treatment focuses on lifestyle changes, medications, medical procedures, and sometimes surgery. Prevention is critical since heart damage is often irreversible.
- A diseased heart can lead to ischemia, heart attacks, insufficient pumping, irregular heartbeats, blood clots, and other complications that reduce quality of life and lifespan.
Clearly, keeping your heart in peak working order is vital for longevity and health. Could CBG oil possibly help? Let’s analyze what early studies reveal about CBG’s effects on the cardiovascular system.
CBG’s Potential Cardiovascular Benefits and Effects
Very little research in humans exists for CBG oil or any CBG product. But results from laboratory tests on cell cultures and animal models suggest CBG may positively impact the heart and circulatory system in the following ways:
Lowers Blood Pressure
High blood pressure, aka hypertension, is a major contributor to heart attack, stroke, artery damage, and heart failure. Research has found CBG may help normalize blood pressure through several mechanisms.
For example, studies show CBG:
- Relaxes blood vessel walls and improves elasticity and blood flow.
- Reduces inflammation in arteries and capillaries.
- Decreases arterial plaque buildup.
- Lowers oxidative damage and free radicals that impact vascular function.
These vascular effects observed in cell culture and animal models indicate CBG has promise for supporting healthy blood pressure. But human studies are still needed.
Improves Cholesterol Levels
Unhealthy cholesterol levels significantly raise heart disease risk. Early results suggest CBG may help maintain normal cholesterol.
For instance, research shows CBG can:
- Lower total cholesterol and triglyceride levels in the blood.
- Reduce accumulation of LDL “bad” cholesterol while elevating “good” HDL cholesterol.
- Limit the oxidation of cholesterol, which makes cholesterol more damaging to arteries.
By optimizing cholesterol balance, CBG could make a big difference in cardiovascular disease risk according to preclinical data. Confirmation in human trials is pending.
Chronic inflammation damages the cardiovascular system and speeds atherosclerosis. CBG displays powerful anti-inflammatory properties that may protect the heart.
Studies find CBG can:
- Suppress inflammatory cytokines and other pro-inflammatory signaling molecules.
- Reduce activation of inflammatory pathways like NF-kB and COX-2.
- Alleviate oxidative stress that triggers inflammation.
These anti-inflammatory actions suggest CBG oil could aid the heart by calming systemic inflammation linked to cardiovascular disease progression.
Provides Antioxidant Effects
Oxidative stress arises when reactive molecules called free radicals overwhelm the body’s antioxidant defenses. This imbalance damages tissues, accelerates aging, and promotes heart disease.
Research shows CBG functions as an antioxidant that may limit this oxidative damage through actions like:
- Neutralizing dangerous superoxide free radicals.
- Increasing production of endogenous antioxidants like glutathione.
- Reducing oxidative stress biomarkers.
Via these antioxidant mechanisms, CBG may support the heart by scrubbing away damaging free radicals before they injure blood vessels and tissues.
Inhibits Platelet Aggregation
When platelets aggregate together, they can form problematic clots that block arteries and cause heart attacks and strokes. Studies indicate CBG may inhibit platelet accumulation.
For example, research finds CBG can:
- Suppress platelet activation and adhesion.
- Reduce factors that increase clotting like thromboxane.
- Improve blood flow and circulation.
These antithrombotic effects suggest CBG could aid cardiovascular health by preventing excessive platelet aggregation and enhancing blood flow.
CBG’s Vascular Mechanisms of Action
Clearly the preliminary research shows promise that CBG oil and other CBG products could benefit the cardiovascular system in multiple ways. But how exactly does CBG impart these heart-healthy effects?
Here’s what researchers understand so far about CBG’s mechanisms of action regarding the heart and circulatory system:
Interacts with the Endocannabinoid System
Like other plant cannabinoids, CBG influences the endocannabinoid system (ECS) - the complex cell signaling network vital for regulating cardiovascular function among other processes.
Studies show CBG can bind to CB1 and CB2 receptors to alter endocannabinoid tone in a manner that reduces inflammation, lowers blood pressure, improves circulation, and provides other cardiovascular benefits.
Reduces Inflammation and Oxidative Stress
In addition to modulating the ECS, CBG also appears to directly reduce inflammation and oxidative stress - two factors intimately involved in cardiovascular disease.
CBG’s antioxidant properties and effects on inflammatory mediators like NF-kB, TNF-alpha, IL-6 and more allow it to target some of the root causes of heart and blood vessel damage.
Impacts Cholesterol and Lipid Pathways
Research indicates CBG influences metabolic pathways related to cholesterol production, transport, oxidation and accumulation. CBG also beneficially alters triglyceride and lipoprotein balances.
Enhances Nitric Oxide Signaling
By increasing nitric oxide production and availability, CBG relaxes vascular muscles, boosts blood flow, and lowers blood pressure through NO-mediated pathways.
The ways CBG positively impacts the cardiovascular system are multifaceted. But the common thread appears to be reducing inflammation and oxidative stress that underlie nearly all forms of cardiovascular disease. More studies are illuminating CBG’s intricate mechanisms of action.
Early Research Into CBG for Heart Conditions
While human research is still minimal, early preclinical studies specifically exploring CBG for certain cardiovascular conditions have produced promising results.
- In hypercholesterolemic rats, CBG reduced total cholesterol while raising HDL cholesterol and lowered markers of oxidative stress. Researchers concluded CBG has “significant potential for the treatment of cardiovascular complications associated with hypercholesterolemia.”
- In rats with diabetes, CBG countered cardiovascular abnormalities induced by the disease. According to researchers, “CBG represents a new potential therapeutic strategy for the treatment of diabetic cardiomyopathy.”
- In mice with induced arthritis, CBG improved dysregulated cardiovascular function caused by excessive inflammation from the condition. Scientists reported CBG produced “a normalization of cardiovascular parameters.”
Though only preclinical evidence, these results bolster the notion that CBG could benefit various heart and cardiovascular conditions characterized by inflammation, oxidative stress, dyslipidemia and related factors. Ongoing studies will clarify CBG’s therapeutic potential.
Other Positive CBG Effects Relevant to Heart Health
In addition to direct cardiovascular impacts, research shows CBG may also benefit the heart and circulatory system indirectly through other whole-body effects.
For instance, CBG shows promise for:
- Regulating blood sugar levels – Helping control diabetes and metabolic disorders that increase heart disease risk.
- Lowering blood pressure – Via relaxing effects on vascular smooth muscles.
- Reducing obesity – By influencing metabolism and fat cell generation in beneficial ways.
- Improving sleep quality – Poor sleep is linked to poorer cardiovascular health.
- Alleviating anxiety – Stress and anxiety contribute to heart issues.
- Reducing pain and muscle spasms – Vasodilation properties improve circulation.
- Neuroprotective effects – May help recover from stroke-induced brain and nerve damage.
The ability of CBG to address wider health issues that often accompany or contribute to heart disease strengthen the case that CBG could be helpful for supporting overall cardiovascular wellbeing.
Optimal Types of CBG Products for Heart Health Support
If interested in trying CBG products for heart health purposes, two excellent options include:
CBG Oils and Tinctures - CBG oils infused with MCT, olive or other carrier oils offer flexibility in dialing in your desired dose. Holding CBG oil under your tongue before swallowing boosts absorption. This allows circulating CBG to exert systemic effects.
CBG Capsules - For convenient dosing without any taste, CBG capsules are ideal. Like CBG oils, capsules provide whole-body effects. Take capsules with food for best absorption.
Other CBG choices like vapes, edibles and topicals center more on localized relief. But for overall cardiovascular benefits, ingestible CBG oils and capsules that reach circulation seem optimal based on the mechanisms involved.
No matter which CBG product you choose, be sure it’s independently tested for purity, safety and potency. Reputable CBG brands will provide up-to-date Certificates of Analysis. This ensures quality and transparency.
Is CBG Safe for Heart Health? Possible Side Effects and Considerations
According to available evidence, CBG appears very safe for most healthy adults when used responsibly. Mild side effects may include:
- Digestive upset – Usually caused by carrier oils or other ingredients. Try a different brand or lower dose.
- Drowsiness – CBG may amplify sedation effects of blood pressure medications. Adjust dose timing if needed.
- Dry mouth – Stay hydrated and effects should subside.
However, people with existing heart conditions or taking certain medications should exercise caution with CBG oil and other CBG products. For example:
- Blood thinners – CBG may heighten anticoagulant effects, raising bleeding risk. Proper dosing minimizes interactions.
- Blood pressure medications – CBG plus antihypertensives may cause BP to drop too low in some cases. Monitor BP closely.
- Supplements that impact heart rate or rhythm – CBG may interact with herbs that affect heart function. Talk to your doctor.
It’s also wise to start with low CBG doses and increase slowly under medical guidance to ensure safety if you have a heart condition or take any heart medications.
While very promising, the cardiovascular benefits of CBG oil remain unproven in humans. Discuss using CBG with your cardiologist, especially if planning to use CBG in place of any doctor-recommended therapies.
Is CBG oil good for heart? Conclusion
The preliminary laboratory research and animal studies exploring CBG oil for heart disease risk factors like hypertension, atherosclerosis, thrombosis, arrhythmias, cholesterol abnormalities and more have produced very promising results.
CBG appears capable of reducing inflammation, oxidative stress, blood pressure, cholesterol levels and other cardiovascular risk factors through a number of mechanisms involving the endocannabinoid system, vasodilation pathways, cholesterol metabolism and more.
However, large scale human studies validating these preliminary findings in living subjects have not yet been conducted. So while extremely hopeful, it’s too soon to state conclusively that CBG oil definitely boosts heart health and fights cardiovascular disease in people.
But the generally impressive safety profile observed for CBG oil and other CBG products means using CBG as an adjunct therapy for supporting heart health is likely low risk for otherwise healthy adults as long as they monitor themselves carefully for side effects.
For those struggling with heart disease risk factors or hoping to prevent cardiovascular problems, trying high quality CBG oil or CBG capsules as part of a heart-healthy lifestyle could be worthwhile. But discuss adding CBG with your doctor first.
While more rigorous clinical trials are still needed, the early preclinical results suggest CBG’s potential for benefiting the heart could make this intriguing cannabinoid a game-changer for cardiovascular medicine.
Frequently Asked Questions About CBG Oil for Heart Health
Does CBG oil lower cholesterol?
Based on preclinical studies, CBG does appear capable of improving several markers of cholesterol like lowering LDL and total cholesterol, raising HDL cholesterol, and reducing accumulation and oxidation of cholesterol. This suggests CBG oil could potentially help optimize cholesterol levels. But human studies are still needed.
Can I take CBG oil while on blood thinners?
It’s best to avoid combining CBG oil with blood thinning medications like warfarin unless closely monitored by your doctor. CBG may heighten the blood thinning effects, raising bleeding risks. Your physician can help determine if using CBG oil with anticoagulants is appropriate for your situation. Never adjust medication doses on your own.
Is CBG oil safe for people with arrhythmias?
Little research exists examining CBG oil for individuals with heart rhythm conditions like atrial fibrillation. While CBG appears low risk based on available data, people with arrhythmias or heart blockages should use caution until more safety studies are conducted. Discuss using CBG oil with your cardiologist first if you have a heart rhythm disorder.
Can CBG oil really lower blood pressure?
The preclinical research showing CBG’s ability to relax vascular muscles and improve blood vessel elasticity and circulation suggests CBG oil could possibly help reduce blood pressure. But human studies confirming this antihypertensive effect have not yet been published. While promising, it’s premature to state definitively CBG lowers BP in people.
How long does it take for CBG oil to work for heart health?
Most people notice subtle benefits from CBG oil within 30-60 minutes as circulating CBG begins interacting with the endocannabinoid system and other pathways involved in cardiovascular function. But the full effects likely take many weeks or even months of sustained use as CBG’s antioxidant and anti-inflammatory actions gradually improve markers of heart health. Patience is key.
Is CBG legal?
Yes, CBG oil and other CBG products are federally legal in the United States as long as they are derived from hemp containing less than 0.3% THC. The 2018 Farm Bill removed hemp and its extracts like CBG from the Controlled Substances Act. However, a few states still prohibit CBG, so check local laws. CBG oil must also meet state labeling and testing requirements.
Resources used to write this article
- Borrelli, F., Pagano, E., Romano, B., Panzera, S., Maiello, F., Coppola, D., De Petrocellis, L., Buono, L., Orlando, P., & Izzo, A. A. (2014). Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis, 35(12), 2787-2797. https://doi.org/10.1093/carcin/bgu205
- Maione, S., Piscitelli, F., Gatta, L., Vita, D., De Petrocellis, L., Palazzo, E., de Novellis, V., & Di Marzo, V. (2011). Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. British journal of pharmacology, 162(3), 584–596. https://doi.org/10.1111/j.1476-5381.2010.01063.x
- Deiana, S. (2013). Potential Synergies of Cannabidiol and Cannabigerol: Implications for Formulation Strategies and Therapeutical Applications. XXXIII National Congress of the Italian Society of Pharmacology. https://www.researchgate.net/publication/323537550_POTENTIAL_SYNERGIES_OF_CANNABIDIOL_AND_CANNABIGEROL_IMPLICATIONS_FOR_FORMULATION_STRATEGIES_AND_THERAPEUTICAL_APPLICATIONS
- Ruhaak, L. R., Felth, J., Karlsson, P. C., Rafter, J. J., Verpoorte, R., & Bohlin, L. (2011). Evaluation of the cyclooxygenase inhibiting effects of six major cannabinoids isolated from Cannabis sativa. Biological and Pharmaceutical Bulletin, 34(5), 774-778. https://doi.org/10.1248/bpb.34.774
- Pagano, E., Capasso, R., Piscitelli, F., Romano, B., Parisi, O. A., Finizio, S., ... & Izzo, A. A. (2016). An orally active cannabis extract with high content in cannabidiol attenuates chemotherapy-induced nausea and vomiting. Scientific reports, 6(1), 1-8. https://doi.org/10.1038/srep35925
- Health Harvard Publishing - Harvard Medical School. (2019). Cannabidiol (CBD) – what we know and what we don't - Harvard Health. https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476.