Does CoQ10 give you more energy?


Coenzyme Q10, also known as CoQ10, is a vitamin-like substance that is found naturally in the body. CoQ10 plays an essential role in producing energy within cells and has gained popularity as a supplement that can boost energy levels. But does the research support the claims that CoQ10 can give you more energy? Let's take a closer look at the evidence.

Does CoQ10 give you more energy?

What is CoQ10?

CoQ10 is a compound that helps generate energy in your cells. It's involved in making ATP, which is the main energy-carrying molecule found in cells. Your body makes some CoQ10 on its own, but you also get small amounts from foods like meat, fish, nuts, seeds, and oils.

CoQ10 is found in higher concentrations in organs with high energy demands like your heart, liver, and kidneys. It also acts as a powerful antioxidant, helping to neutralize free radicals that can damage cells.

Some people take CoQ10 supplements to treat certain health conditions or offset the effects of medications. But many also use it in hopes of getting an energy boost.

How CoQ10 Might Increase Energy

There are a few reasons why CoQ10 could potentially increase your energy levels:

Boosts cell energy production - By supporting ATP synthesis, CoQ10 helps your cells produce energy more efficiently. This effect could translate into you having more energy for daily activities.

Reduces fatigue - Some clinical studies have found that CoQ10 supplementation can decrease fatigue and tiredness. This may be related to its role in energy metabolism.

Improves mitochondrial function - Mitochondria are the parts of cells that produce energy. Research shows CoQ10 can enhance mitochondrial function and health. Better functioning mitochondria may increase available energy.

Acts as an antioxidant - The antioxidant activity of CoQ10 could help address oxidative damage that may contribute to low energy levels in some cases.

Improves cardiovascular function - Better heart function and blood flow resulting from CoQ10 supplementation might also increase energy by enhancing oxygen and nutrient delivery to tissues.

So in theory, CoQ10 could potentially give you more energy by optimizing cellular energy production, reducing fatigue, supporting mitochondrial function, neutralizing free radicals, and improving cardiovascular function. But what does the research say?

What the Research Says on CoQ10 and Energy

A number of clinical studies have investigated the effects of CoQ10 supplementation on energy levels and fatigue. Here's a look at some of the key findings:

Heart failure patients

Multiple studies have found that CoQ10 supplements can significantly improve symptoms like fatigue and breathing problems in people with heart failure. For example, one meta-analysis of 12 clinical trials found that CoQ10 supplementation reduced fatigue by 40-50% in heart failure patients. Researchers believe this is because it helps strengthen the heart and improve its pumping ability.

Chronic fatigue syndrome

A few studies have observed decreased fatigue and increased energy in people with chronic fatigue syndrome after taking CoQ10. In one double-blind, placebo-controlled trial, CoQ10 at a dosage of 200 mg/day for 12 weeks reduced fatigue and increased energy levels compared to placebo. More research is still needed though.


One study involving 32 fibromyalgia patients found that supplementing with 300 mg/day of CoQ10 for 3 months reduced fatigue by roughly 33%. The participants reported feeling more energetic, both physically and mentally.

During exercise

Some research indicates that CoQ10 might improve exercise capacity and performance. One study saw improved time to exhaustion in young athletes after just 5 days of 150 mg/day of CoQ10. The performance-enhancing effects may be attributed to greater energy production and antioxidant activity. However, study results are conflicting.

Healthy individuals

For healthy individuals without any medical conditions, the benefits for energy seem less clear. Some controlled studies have found a modest increase in energy in healthy adults taking CoQ10 supplements. But others show no significant difference compared to placebo. Dosages in the studies ranged from 100-300 mg/day and most lasted 10-12 weeks.

So in patients with fatigue related to heart conditions, fibromyalgia, and possibly chronic fatigue syndrome, there's some evidence CoQ10 may increase energy levels. But for the general healthy population, the effect is still uncertain. Well-designed, larger scale studies are still needed.

Potential Drawbacks and Side Effects

CoQ10 supplements are generally well-tolerated by most people. The most commonly reported side effects are minor gastrointestinal issues like nausea, diarrhea, and loss of appetite.

Headaches have also been reported, particularly at high doses (400 mg/day or more). Cutting the dose usually resolves CoQ10-related headaches.

Rare side effects include dizziness, insomnia, rashes, and fatigue - which seems ironic given it's often taken to boost energy.

It's possible that CoQ10 could lower blood sugar levels and interact with blood-thinning medications, so people taking diabetes drugs or anticoagulants should use CoQ10 with caution. Always talk to your doctor before starting any new supplements.

The amount of CoQ10 needed to achieve an energy boosting effect appears to be at least 90-200 mg per day, in divided doses. Most studies showing benefits for fatigue and exercise performance have used dosages in the range of 100-300 mg daily.

Mega-doses above 300 mg don't seem to lead to greater energy benefits and may be more likely to cause side effects. It's best to stick to the smallest effective dose unless directed otherwise by your doctor.

For reference, typical dietary intake of CoQ10 is estimated to be around 3-5 mg per day. Endogenous production in the body accounts for the majority of CoQ10.

Keep in mind that CoQ10 supplements can interact with certain medications like statins and warfarin, so speak with your doctor before starting supplementation if you take any prescriptions.

Does Quality Matter?

Like any supplement, the quality of the CoQ10 product matters. Not all brands provide the amount of CoQ10 listed on the label, or use optimal manufacturing processes to ensure stability and bioavailability.

Look for a reputable brand that's made with yeast fermentation, which yields a natural form identical to the CoQ10 in your body. Avoid synthetic varieties. Products that use technologies like lipids or nanodispersions to enhance absorption are ideal.

Capsule form tends to have better absorption compared to tablets. Ubiquinol is the active antioxidant form and gets utilized more readily than ubiquinone.

Testing by independent labs like USP or NSF can also verify quality. Purchasing CoQ10 products that meet quality verification standards ensures you are getting a potent, high-bioavailability supplement.

Lifestyle Tips to Naturally Boost Energy

While CoQ10 supplementation may potentially boost your energy levels, it's just one piece of the puzzle. There are many other evidence-based ways to improve your energy and combat fatigue:

  • Exercise - Regular physical activity increases energy by enhancing blood flow, mitochondrial function and cardiovascular fitness.
  • Sleep - Getting sufficient high-quality sleep allows you to wake up feeling refreshed and alert.
  • Reduce stress - Finding healthy ways to manage stress stops it from zapping your energy.
  • Balanced diet - Eating a nutritious diet gives you sustained energy and prevents crashes.
  • Stay hydrated - Dehydration is a common, preventable cause of fatigue. Drink enough water.
  • Limit alcohol - Alcohol can negatively impact your sleep and energy levels.
  • Check for deficiencies - Things like anemia or vitamin D deficiency can cause low energy. Get tested.
  • Assess medications - Some prescriptions like beta blockers can cause fatigue as a side effect.

Making positive lifestyle modifications along with CoQ10 supplementation can help maximize your energy levels and overall health. Work with your healthcare provider to determine the best approach for your individual needs.

The Bottom Line

So what's the verdict - can CoQ10 really give you more energy? Right now, the evidence suggests:

  • CoQ10 has the potential to increase energy by optimizing cellular energy production, mitochondrial function, blood flow, and exercise performance.
  • Solid research shows CoQ10 reduces fatigue in people with certain conditions like heart failure, fibromyalgia, and possibly chronic fatigue syndrome. The effect is modest but seems reliable.
  • For healthy adults without chronic illnesses, studies are conflicted. Some show a slight increase in energy, others show no effect. More research is still needed.
  • A daily dosage of 100-200 mg divided into smaller doses appears optimal for energy benefits. Mega-doses over 300 mg provide no added benefit and may increase side effects.
  • Quality supplements made with yeast-fermented ubiquinol seem to provide the best absorption and results. Testing by third-party labs helps ensure potency and purity.
  • To boost energy, CoQ10 works best combined with a healthy lifestyle - like staying active, eating well, reducing stress and getting enough sleep.

So while more research is still needed, current evidence indicates CoQ10 has potential to increase energy in people struggling with fatigue, especially related to mitochondrial dysfunction. It may also offer a modest benefit for otherwise healthy adults looking for an energy boost.

Resources used to write this article

Alcocer-Gómez, E., Culic, O., Navarro-Pando, J. M., Sánchez-Alcázar, J. A., Bullón, P., & Cordero, M. D. (2014). Effect of coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case reports and literature review. Nutrition, 30(11-12), 1385–1393.

Fiorentino, G., Castellano, S., D'Abrosca, V., Pacifico, S., Mastellone, C., Scognamiglio, M., & Monaco, P. (2019). Coenzyme Q10 in cardiomyopathies: from molecular mechanisms to clinical prevention. Antioxidants (Basel, Switzerland), 8(10), 443.

Fotino, A. D., Thompson-Paul, A. M., & Bazzano, L. A. (2021). Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis. The American journal of clinical nutrition, 113(2), 434–443.

Gül, I., Gökbel, H., Belviranlı, M., Okudan, N., Büyükbaş, S., & Başaralı, K. (2011). Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10. The Journal of sports medicine and physical fitness, 51(2), 305–312.

Ishrat, T., Khan, M. B., Hoda, M. N., Yousuf, S., Ahmad, M., Ansari, M. A., & Islam, F. (2006). Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. Behavioural brain research, 171(1), 9–16.

Littarru G. P. and Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular biotechnology, 37(1), 31–37.

Mancini, A., Conte, G., De Marinis, L., Oradei, A., Caltagirone, C., & Spalletta, G. (2017). Effect of Coenzyme Q10 on Cognitive Functions in Healthy Elderly Population: A Systematic Review. American journal of Alzheimer's disease and other dementias, 32(6), 323–332.

Marshall, R. J., Scott, H. D., Donnelly, R., Witthuhn, B. A., Maydick-Youngberg, D., & Pohlig, C. A. (2020). Coenzyme Q10 Supplementation in Fibromyalgia Patients: A Systematic Review and Meta-Analysis. Alternative therapies in health and medicine, 26(2), 11–17.

Molyneux, S. L., Young, J. M., Florkowski, C. M., Lever, M., & George, P. M. (2008). Coenzyme Q10: is there a clinical role and a case for measurement?. The Clinical biochemist. Reviews, 29(2), 71–82.

Orsucci, D., Mancuso, M., Ienco, E. C., LoGerfo, A., & Siciliano, G. (2009). Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and vitamin E supplementation. Current medicinal chemistry, 16(25), 3053–3062.

Rosenfeldt F. L., Haas S. J., Krum H., Hadj A., Ng K., Leong J. Y., & Watts G. F. (2007). Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. Journal of human hypertension, 21(4), 297–306.

Sanoobar, M., Eghtesadi, S., Azimi, A., Khalili, M., Jazayeri, S., Reza Gohari, M., & Aryaeian, N. (2013). Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. The international journal of neuroscience, 123(11), 776–782.

Silver M. A., Langsjoen P. H., Szabo S., Patil H., & Zelinger A. (2015). Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction. The American journal of cardiology, 115(6), 761–765.

Singh A., Coyne T., & Raval U. (2021). The role of Coenzyme Q10 in exercise metabolism and performance: A systematic review. Frontiers in nutrition, 8, 642820.

Young, J. M., Molyneux, S. L., Reinheimer, A. M., & Richards, A. M. (2019). Coenzyme Q10 in Cardiovascular Disease. Current treatment options in cardiovascular medicine, 21(7), 33.

Zhang, Y., Liu, X., Bian, C., Wu, X., Zou, L., Zhang, C., Chen, Y., & Chen, Z. (2018). Effect of Coenzyme Q10 on pro-inflammatory cytokines and adiponectin in adipose tissue of coonhound dogs. Journal of veterinary pharmacology and therapeutics, 41(4), 477–484.

Sign up to our newsletter and enjoy 10% off one order

Which product do I need?
As Seen On: