Can i take Q10 with fish oil?


Coenzyme Q10 (CoQ10) and fish oil are two of the most popular dietary supplements on the market today. Both offer a variety of potential health benefits, from supporting heart health to reducing inflammation. But can you safely take CoQ10 and fish oil together? Here’s what you need to know.

can i take coq10 with fish oil?

A Brief Overview of CoQ10 and Fish Oil

Before diving into whether these two supplements can be combined, let’s first go over the basics of what each one is and does.

What is CoQ10?

  • CoQ10 is a naturally occurring compound produced by the body that acts as an antioxidant and plays a vital role in energy production in cells.
  • It supports mitochondrial function, heart health, exercise performance, brain health, and more.
  • Food sources include meat, fish, nuts, seeds, and oils, but CoQ10 supplementation may provide higher doses.
  • Common supplements include ubiquinone and ubiquinol forms. Ubiquinol is considered more bioavailable.

What is Fish Oil?

  • Fish oil supplements provide omega-3 fatty acids EPA and DHA, which have anti-inflammatory effects.
  • Omega-3s support heart, brain, eye, joint, and mental health. They may also aid weight management.
  • Fish like salmon and tuna are rich sources, but supplements ensure higher, more consistent omega-3 intake.
  • Look for quality products that filter out toxins and use sustainable fishing practices.

Potential Benefits and Side Effects of Each

To determine if these supplements can be safely combined, it’s important to first review the potential upsides and downsides of taking each one individually:

Potential Benefits of CoQ10

  • Heart health - CoQ10 assists in energy production in heart muscle cells and acts as an antioxidant. Studies show CoQ10 supplementation may:
    • Improve symptoms in heart failure patients
    • Reduce risk of repeat heart attacks
    • Help manage high blood pressure
    • Lower cholesterol
    • Improve outcomes post-heart surgery
  • Diabetes - Some research indicates CoQ10 may improve insulin sensitivity and blood sugar control.
  • Fertility - CoQ10 may improve egg quality and pregnancy rates.
  • Exercise - Early findings suggest CoQ10 boosts athletic performance and speeds post-workout recovery.
  • Brain health - Its antioxidant effects may support cognitive function and offer neuroprotective benefits.
  • Migraines - CoQ10 appears to reduce frequency and severity of migraine headaches.
  • Side effects - Generally well tolerated even at high doses. Mild side effects like digestive upset, insomnia, and headaches may occur. Those on warfarin or certain medications should consult a doctor before supplementing.

Potential Benefits of Fish Oil

  • Heart disease - Omega-3s reduce triglycerides, lower blood pressure, improve artery function, and have anti-inflammatory and anti-clotting activity. This translates to lower heart disease risk.
  • Cholesterol - Fish oil increases HDL (good) cholesterol and reduces elevated triglycerides.
  • Brain health - DHA specifically supports brain development, cognition, and mood. May benefit Alzheimer’s and dementia.
  • Eye health - DHA accumulates in the retina and promotes eye development. Linked to reduced macular degeneration.
  • Pregnancy - Omega-3s support fetal brain growth and development. May reduce risk of preterm birth.
  • Side effects - Generally considered safe. Possible side effects include fishy aftertaste, nausea, digestive upset, and loose stools. Those on blood thinners should exercise caution. Contamination is also a concern with fish oil.

Do CoQ10 and Fish Oil Interact?

With a basic understanding of each supplement under your belt, the next question is: do CoQ10 and fish oil interact when taken together?

The short answer is that no negative interactions have been reported when combining CoQ10 and fish oil. Small studies have even found positive synergistic effects on heart health when CoQ10 and omega-3s are administered together:

  • A study in 42 patients with acute myocardial infarction found that combining CoQ10 and omega-3s significantly improved left ventricular function compared to omega-3s alone.
  • Another trial in heart failure patients showed that supplementing with both CoQ10 and fish oil increased antioxidant activity markers compared to either supplement alone.
  • An animal study showed CoQ10 may enhance the absorption and bioavailability of omega-3s. Mice fed CoQ10 and fish oil had higher plasma EPA and DHA levels compared to mice fed fish oil alone.

So not only are there no adverse interactions, but emerging research indicates combining them may provide synergistic cardiovascular benefits. More human studies are still needed to confirm this effect.

How Do CoQ10 and Fish Oil Affect Heart Health?

Heart health is one of the most popular reasons people take CoQ10 and fish oil. Let’s take a closer look at how each nutrient specifically influences cardiovascular function and disease risk:

CoQ10 and Heart Health

  • Cholesterol - CoQ10 may reduce LDL (bad) cholesterol while boosting HDL cholesterol. It also lowers Lp(a), an inflammatory marker.
  • Blood pressure - Studies show CoQ10 supplementation can lower blood pressure levels in those with hypertension.
  • Heart failure - By improving cellular energy production, CoQ10 enhances heart function and symptoms in heart failure patients.
  • Stroke - CoQ10’s antioxidant activity may reduce damage caused by ischemia-reperfusion injury during stroke.
  • Statins - CoQ10 levels deplete with statin use. Supplementing may help manage statin side effects like muscle pain.
  • Surgery - Pre-treatment with CoQ10 prior to heart surgery reduces complication rate and ICU stay.

Fish Oil and Heart Health

  • Arrhythmia - Omega-3s reduce inflammation that can trigger irregular heart rhythms like atrial fibrillation.
  • Triglycerides - Fish oil reliably lowers elevated triglyceride levels, a cardiovascular risk factor.
  • Blood pressure - EPA and DHA demonstrate modest blood pressure-lowering effects.
  • Plaque stability - Omega-3s may stabilize arterial plaque, reducing risk it will rupture and cause clots.
  • Heart attack - Eating fish regularly linked to lower heart attack incidence. Omega-3s may cut future heart attack risk by 10%.
  • Stroke - Omega-3 intake linked to reduced ischemic stroke risk. May also limit damage from stroke.

So while their mechanisms differ, both offer anti-inflammatory, antioxidant, cholesterol-balancing, and blood pressure-optimizing effects that benefit the heart and arteries.

CoQ10 and Fish Oil for Diabetes

Along with cardiovascular benefits, some research suggests both CoQ10 and fish oil may also provide advantages for those with diabetes or metabolic disorders:

  • In small studies, CoQ10 has been shown to lower blood sugar levels, improve insulin secretion, and increase insulin sensitivity in diabetic patients. These effects may result from CoQ10’s ability to improve mitochondrial function and reduce oxidative stress. Larger trials are still needed.
  • Observational studies link higher blood levels of omega-3s with a reduced risk of developing type 2 diabetes. Fish oil also boosts adiponectin, an insulin-sensitizing hormone, and may aid weight loss. Clinical research indicates it helps manage elevated triglycerides in diabetic patients too.
  • One study found combining CoQ10 and omega-3s decreased insulin resistance, blood sugar, and inflammation markers in women with polycystic ovarian syndrome (PCOS), a condition linked to increased diabetes risk.

More research is required, but these preliminary findings suggest both nutrients may provide therapeutic adjuncts for diabetes management.

Dosage Recommendations for CoQ10 and Fish Oil

So how much CoQ10 and fish oil should you take to achieve benefits? Here are some general dosage guidelines:

  • CoQ10 - Doses used in studies for heart benefits range from 100-600 mg/day, taken in divided doses with fat-containing meals to enhance absorption. Those with heart failure or on statin medications may require higher doses, so speak to your doctor.
  • Fish oil - Aim for a combined total of at least 500-1000 mg/day of omega-3s EPA and DHA. This typically requires 1-3 grams of fish oil daily. Higher doses around 2-4 grams per day are often used for elevated triglycerides. Dividing the dose reduces side effects.
  • Combined doses - Effective combinations used in research include 200 mg CoQ10 with 500 mg fish oil twice daily, or 100 mg CoQ10 with 1000 mg fish oil daily.

Always read supplement labels closely and speak with a healthcare provider to find the right dosages tailored to your health needs and goals. Testing nutrient levels can also help determine optimal intake amounts.

Top Food Sources of CoQ10 and Omega-3s

In addition to supplements, you can obtain CoQ10 and omega-3s naturally by including more foods that provide these nutrients in your diet:

CoQ10 Food Sources

  • Organ meats - Heart, kidney, liver
  • Muscle meats - Beef, pork, chicken
  • Oily fish - Herring, mackerel, trout, tuna
  • Vegetable oils - Soybean, sesame, canola
  • Nuts and seeds - Peanuts, pistachios, sunflower seeds
  • Legumes - Soybeans, lentils, beans

Omega-3 Food Sources

  • Fatty fish - Salmon, mackerel, sardines, herring
  • Plant foods - Chia seeds, flaxseeds, walnuts
  • Grass-fed beef
  • Enriched eggs
  • Fortified foods - Milk, yogurt, juices
  • Algal oil

Aim to include a few servings per week of omega-3-rich fish like salmon while also eating nuts, seeds, plant oils, beans, and organ meats to obtain some CoQ10 as part of a balanced diet.

Choosing Quality CoQ10 and Fish Oil Supplements

When searching for CoQ10 and fish oil supplements, follow these buying tips:

For CoQ10:

  • Select the ubiquinol form for optimal absorption
  • Seek out emulsified products to enhance bioavailability
  • Choose reputable, third-party tested brands
  • Timed-release formulas can provide sustained benefits
  • Avoid purchasing based on price alone

For Fish Oil:

  • Look for pharmaceutical-grade, molecularly distilled oils
  • Ensure proper third-party testing for purity and potency
  • Choose sustainably sourced oils
  • Store in refrigerator to prevent rancidity
  • Take enteric-coated capsules to minimize “fish burps”

Buying high-quality supplements from trustworthy manufacturers can help maximize benefits and avoid potential contaminants.

Should You Take CoQ10 and Fish Oil Together?

Based on the available evidence, combining CoQ10 and fish oil appears safe and potentially advantageous thanks to their complementary antioxidant and cardioprotective effects. Those with heart disease or diabetes may derive particular benefit from supplementing with this duo.

However, some considerations include:

  • Speak with your doctor first, especially if taking any medications or if you have underlying health conditions
  • Watch for possible additive side effects like digestive upset or insomnia
  • Stick to recommended dosages of each nutrient
  • Choose high-quality supplements from reputable brands
  • Get nutrient levels tested to hone in on ideal intake amounts

Overall, pairing CoQ10 and fish oil can be a safe, research-backed way to promote heart health, help manage diabetes, and reduce inflammation when done under medical supervision. But more studies are still needed to determine optimal combined doses and ratios. As with any supplement regimen, take an individualized approach tailored to your specific health status, needs, and goals.

Can i take Q10 with fish oil? Conclusion

In conclusion, current evidence indicates CoQ10 and fish oil can be safely taken together. Small studies suggest combining them may actually provide synergistic effects on antioxidant status, cardiovascular function, and diabetes parameters. Both offer well-established heart health and anti-inflammatory benefits, making them a popular supplement stack. However, stick to recommended dosages of each, select high-quality products, and get medical guidance to achieve optimal results. More research is still warranted to fully understand how CoQ10 and omega-3s interact and influence health outcomes when co-supplemented. But the current data is promising in terms of safety and potential complementary advantages.

Facts About Combining CoQ10 and Fish Oil

  • CoQ10 and fish oil (omega-3s) are two of the most common dietary supplements that promote heart health.
  • No negative interactions have been reported when CoQ10 and fish oil are taken together. Small studies suggest they may have synergistic cardiovascular effects when combined.
  • CoQ10 benefits the heart through its role in energy production and antioxidant activity. Fish oil provides anti-inflammatory effects that protect the heart and arteries.
  • Both nutrients show promise for managing aspects of diabetes like insulin resistance and high blood sugars, especially when combined.
  • Effective daily dosages used in studies include 100-600 mg for CoQ10 and 500-1000 mg for fish oil (EPA/DHA).
  • Food sources of CoQ10 include organ meats, muscle meats, fish, and vegetable oils. Omega-3s are found in fatty fish, nuts/seeds, oils, and fortified foods.
  • High-quality supplements from reputable brands, taken as recommended under medical guidance, can help maximize benefits and safety.
  • More research is still needed on the ideal ratios, dosages, and long-term effects of combining CoQ10 and omega-3s. But current evidence supports their combined use for improved heart disease parameters.
  • Those taking medications or with underlying health conditions should speak to a doctor before supplementing with CoQ10 and fish oil together.


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