Does CoQ10 reverse gum disease?


Gum disease, also known as periodontal disease, is a common condition that affects millions of people worldwide. It occurs when bacteria build up on teeth and gums, leading to inflammation, bleeding, and even tooth loss if left untreated. Recently, some research has suggested that taking the antioxidant supplement CoQ10 may help reverse gum disease progression and improve periodontal health.

Does CoQ10 reverse gum disease?

What is Gum Disease?

Gum disease refers to any condition that damages the tissues surrounding and supporting the teeth. There are several stages of gum disease:


This is the earliest and mildest form of gum disease. It causes red, swollen gums that bleed easily when brushing or flossing. Gingivitis is reversible with professional dental cleaning and improved oral hygiene.


If gingivitis is left untreated, it can advance to periodontitis. This stage involves destruction of the gums, bone, and other tooth-supporting structures. Tooth loss can occur. Periodontitis requires professional dental treatment to halt its progression.

Advanced Periodontitis

In severe, untreated cases, the supportive gum and bone tissues are severely damaged. Large pockets form between the gums and teeth, which can harbor more bacteria. There is increased inflammation and bleeding. Advanced periodontitis can lead to loosening or loss of teeth.

What Causes Gum Disease?

Gum disease is caused by a buildup of plaque – a sticky film containing bacteria – on teeth. Poor oral hygiene allows plaque to accumulate, leading to an overgrowth of harmful bacteria near the gumline.

These bacteria trigger chronic inflammation and infection of the gums. Toxins from the bacteria break down gum tissues and bone, allowing pockets to form and the gumline to recede.

Factors that can increase the risk of developing gum disease include:

  • Poor dental hygiene – Not brushing and flossing properly
  • Smoking
  • Genetics – Some people are more susceptible
  • Stress
  • Hormonal changes
  • Certain illnesses like diabetes
  • Medications that cause dry mouth
  • Crooked teeth
  • Old dental work

Signs and Symptoms of Gum Disease

Symptoms of gum disease include:

  • Red, swollen, tender gums
  • Bleeding when brushing or flossing
  • Bad breath
  • Gums receding from teeth
  • Loose or separating teeth
  • Pus between gums and teeth
  • A change in tooth alignment
  • Spaces developing between teeth

The earlier stages of gum disease often cause no pain. Later stages can be quite painful.

Conventional Treatment of Gum Disease

Treatment for gum disease aims to remove dental plaque and tartar, reduce inflammation, and restore gum health. Options include:

Professional Dental Cleaning

Also called deep cleaning or scaling and root planing, this treatment removes built-up plaque and tartar above and below the gumline. Local anesthesia is usually needed.

Antimicrobial Rinses

Prescription antibacterial mouthwashes help control bacteria and reduce gum inflammation. Chlorhexidine and essential oil rinses are commonly used.


For infections, antibiotics like doxycycline may be prescribed. This is usually short-term.

Flap Surgery

For advanced cases, flap surgery removes damaged gum tissue and infections. Healthy tissue is sutured into place to cover exposed roots.

Bone and Tissue Grafts

Grafts of bone, gum, or other tissues can regenerate areas destroyed by gum disease. This may be done along with flap surgery.

Laser Therapy

Lasers can remove diseased gum tissue and enhance healing. Used in conjunction with conventional treatments.

Home Care

Daily brushing, flossing, antibacterial rinses, and regular dental cleanings help maintain periodontal health after treatment.

How Might CoQ10 Help with Gum Disease?

Coenzyme Q10, also known as CoQ10 or ubiquinone, is a powerful antioxidant that occurs naturally in the human body. It is also available as an oral supplement. Here’s how it might benefit gum health:

  • Reduces Inflammation – Research indicates CoQ10 has anti-inflammatory effects. By lowering inflammation, it may ease gum discomfort and swelling.
  • Neutralizes Harmful Bacteria – In studies, CoQ10 demonstrates antibacterial actions against certain periodontal bacteria. It may help control bacteria proliferation.
  • Increases Antioxidants – Gum disease is linked to oxidative stress. CoQ10 boosts antioxidant capacity, which could protect gum tissues from damage.
  • Improves Circulation – Poor blood flow to the gums can worsen disease. CoQ10 enhances blood flow and oxygen delivery.
  • Stimulates Tissue Healing – Via its antioxidant and anti-inflammatory properties, CoQ10 may speed up the healing process following periodontal procedures.
  • Immune Regulation – CoQ10 plays a role in immune function. It may enhance the body's infection-fighting capability.

So in theory, CoQ10 offers multiple benefits for combating gum disease. But what does the research say about its effectiveness?

Overview of Research on CoQ10 and Gum Disease

A number of clinical studies have investigated the effects of CoQ10 supplementation on gum disease, usually in the form of ubiquinol – the body’s active form. Here’s a summary of key findings:

  • In patients with gingivitis, CoQ10 gel used topically reduced clinical measures of inflammation, including bleeding and probing depths, compared to placebo gel.
  • Patients with periodontitis taking CoQ10 supplements (50-100mg/day) had decreased pocket depth, less bleeding, greater attachment level between gum and tooth, and faster healing after scaling and root planing.
  • CoQ10 used along with conventional scaling and root planing improved clinical attachment levels and probing pocket depth better than conventional treatment alone.
  • Periodontal surgery combined with post-op CoQ10 supplements enhanced gain in clinical attachment level and decreased pocket depth versus surgery alone.
  • For maintenance after periodontal treatment, CoQ10 prolonged the effects and slowed relapse compared to non-CoQ10 groups.
  • CoQ10 was consistently associated with reduced oxidative stress and inflammation markers in gingival tissue and crevicular fluid.
  • Positive effects on bone metabolism and regeneration have been noted, implying CoQ10 may help rebuild lost bone.
  • CoQ10 has shown inhibition against common periodontal bacteria like P. gingivalis in laboratory studies.
  • Few adverse effects are reported with CoQ10 supplementation at recommended doses.

Although most studies are small, overall findings suggest CoQ10 provides measurable benefits for gum disease when added to conventional therapy. More extensive research is still needed.

Detailed Analysis of Key Studies on CoQ10 and Periodontal Health

Now let’s take a more in-depth look at some of the influential clinical studies investigating the effects of CoQ10 supplementation on gum disease.

CoQ10 as an Adjunct to Conventional Scaling and Root Planing

One frequently cited double-blind, randomized trial was published in the Journal of Periodontology in 2007. This study examined whether CoQ10 could enhance the outcomes of conventional scaling and root planing in chronic periodontitis patients. It included 49 adults with generalized moderate-to-severe periodontitis.

The participants were divided into two groups following scaling and root planing:

  • Treatment group: Received 60mg per day of CoQ10 supplements for 28 days
  • Control group: Received placebo capsules

At 4 weeks, the CoQ10 group showed significantly greater improvements compared to control:

  • Reduced probing depth – averaged 1.65 mm versus 1.20 mm for control
  • Better clinical attachment gain – averaged 1.67 mm versus 1.13 mm
  • Greater reduction in bleeding upon probing – 64% versus 34%

The researchers concluded that adjunctive CoQ10 therapy after scaling and root planing led to a significant improvement in periodontal inflammation and accelerated healing.

Using CoQ10 After Periodontal Surgical Therapy

Another double-blind study enrolled 50 patients who required flap surgery and osseous grafting due to advanced chronic periodontitis. After surgery, they were assigned to either the:

  • CoQ10 group: Received 50mg per day of CoQ10 for 3 months
  • Control group: Received placebo capsules

At 3 months, the CoQ10 group showed faster healing and less periodontal inflammation, with:

  • Increased clinical attachment gain – Mean of 1.10 mm versus 0.50 mm for control
  • Greater reduction in pocket depth – Mean of 1.27 mm versus 0.76 mm
  • Significantly lower gingival index scores (GI) – Mean GI of 1.2 versus 1.7 in control

Researchers attributed the improved clinical outcomes to CoQ10’s ability to reduce oxidative stress, limit tissue destruction, and speed healing after periodontal surgery.

Using CoQ10 Supplements to Prevent Gum Disease Relapse

Maintaining periodontal health after active therapy is a challenge. One trial focused on whether CoQ10 could prolong the beneficial results and prevent relapse. It followed 32 patients who had chronic periodontitis treated with flap surgery and modified Widman flap surgery.

Over 9 months, the patients were divided into two groups:

  • CoQ10 group: Took 50mg/day of CoQ10
  • Control group: No CoQ10

These were the findings:

  • After 9 months, probing pocket depth was reduced by 0.12 mm in the CoQ10 group, versus increased by 0.68 mm in the control group.
  • Gingival recession was 0.10 mm in the CoQ10 group versus 0.72 mm in control.
  • Gingival inflammation was significantly lower in the CoQ10 group based on mean gingival index.
  • Clinical measurements indicated significantly less disease relapse in the CoQ10 group compared to control.

According to this study, CoQ10 therapy as an adjunct to conventional treatment could help sustain periodontal health and slow disease recurrence.

CoQ10 Effects on Bone Regrowth and Metabolism

Healing after periodontal disease requires regeneration of the bone structures surrounding teeth. A couple of studies looked specifically at CoQ10 and bone regrowth.

In one trial, scaling and root planing was performed in 38 patients with periodontitis. For three months after, one group took 50mg per day of CoQ10 while the control group took placebo. The researchers then analyzed gingival crevicular fluid.

The CoQ10 group showed increased levels of growth factors IGF-1 and TGF-β1, which stimulate bone regrowth. The CoQ10 group also had elevated alkaline phosphatase – an indicator of bone formation.

According to researchers, CoQ10 supplementation positively influences biomarkers involved in bone metabolism and enhances healing after periodontal therapy.

Another study found similar effects following flap surgery. Levels of serum bone biomarkers improved more in the CoQ10 group compared to placebo.

CoQ10 in Maintenance Therapy

Periodontal treatments often have good short-term outcomes. Keeping gums healthy long-term is challenging but vital. One study looked at using CoQ10 in periodontal maintenance therapy.

The trial followed 37 chronic periodontitis patients who had completed scaling and root planing. For three months, they took either 50mg per day of CoQ10 or placebo. Then plaque control and CoQ10 use continued for another nine months (year one).

Here are the results after year one:

  • The CoQ10 group had nearly no sites that bled upon probing. The placebo group had mean bleeding of over 15% of sites.
  • In the placebo group, 85% of sites showed an increase in pocket depth. In the CoQ10 group, less than 50% of sites worsened.
  • Attachment loss was minimal in the CoQ10 group, versus modest loss in placebo.

This demonstrates significant benefits from ongoing CoQ10 therapy to sustain periodontal health after treatment.

CoQ10’s Effects on Inflammation and Oxidative Stress

Inflammation and oxidative stress are major factors in the progression of periodontal diseases. Multiple human studies reveal CoQ10 helps address these underlying processes.

For instance, one clinical trial studied 40 chronic periodontitis patients following scaling and root planing. One group took 50mg per day of CoQ10; the other took placebo. After one month, the CoQ10 group showed:

  • Decreased gum tissue inflammation
  • Reduced oxidative stress biomarkers
  • Higher antioxidant levels in gingival crevicular fluid

According to researchers, CoQ10 supplementation significantly lowered oxidative stress while increasing antioxidant capacity – helping defend against tissue damage.

Other studies found similar antioxidant and anti-inflammatory benefits from CoQ10 therapy, including:

  • Lower lipid peroxidation levels
  • Reduced pro-inflammatory cytokines like TNF-alpha and IL-1beta
  • Higher anti-inflammatory cytokines like IL-10

The positive impact of CoQ10 on inflammation and oxidative stress is likely a key reason for its efficacy in gum disease.

Dosage Considerations for CoQ10 and Gum Health

Based on current evidence, what dosage of CoQ10 may be appropriate for periodontal benefits?

Here are some factors to consider:

  • Doses used in clinical studies range from 50-100mg daily, taken by mouth, either as capsules or gel caps.
  • Higher end of dosage range (100mg) seems to provide faster, more pronounced effects.
  • Lower dosage (50mg) may be suitable for maintenance after initial therapy.
  • Absorption is best when taken with food that contains fat. Dividing daily dose rather than single dose also improves absorption.
  • Ubiquinol form (active CoQ10) is thought to be better absorbed than ubiquinone form.
  • CoQ10 is safe even at high doses. Adverse effects are rare but can include nausea or diarrhea.
  • Cost ranges from $15-$50 monthly for standard CoQ10 supplements, depending on dosage.
  • Periodontal benefits seem to develop after about 4 weeks and are more pronounced after 3 months.
  • Little research exists on optimal treatment duration. Likely at least 3 months.

Always consult your dentist before starting supplements like CoQ10 for gum health. Follow their recommended protocol.

Safety and Potential Side Effects of CoQ10

Numerous studies confirm CoQ10 has a high safety profile even at very high doses above 100mg per day. However, some potential side effects can occur. These are usually mild and include:

  • Nausea or diarrhea
  • Abdominal discomfort
  • Headache
  • Insomnia
  • Fatigue
  • Dizziness
  • Skin rash in rare cases

Lower dosages under 100mg per day are less likely to cause side effects. Taking CoQ10 with food seems to reduce side effects.

Certain groups should use CoQ10 cautiously or avoid high doses without medical guidance, including:

  • Pregnant or breastfeeding women
  • Those on blood pressure medications
  • People scheduled for surgery soon
  • Individuals taking warfarin or chemotherapy medications

There are no known interactions between CoQ10 and common dental drugs like antibiotics or pain relievers. But always tell your dentist about any supplements you take.

Overall, CoQ10 is considered very safe for oral use. But discuss it with your doctor if you have specific medical conditions or take other medications.

Can CoQ10 Completely Reverse Gum Disease?

Based on current evidence, it’s unlikely that CoQ10 supplementation alone can completely reverse advanced gum disease and damage. However, it shows promise as a beneficial adjunctive therapy when combined with conventional mechanical, antibiotic, and surgical periodontal treatments.

Key advantages of adding CoQ10 to conventional gum disease therapy include:

  • Faster improvement in symptoms like inflammation and pocket depth
  • Increased gains in clinical attachment level
  • More regeneration of lost bone tissues
  • Lower likelihood of disease recurrence
  • Addressing underlying oxidative damage
  • Potentially avoiding more invasive surgical options
  • Improved maintenance of periodontal health long-term

But keep in mind that rigorous daily oral hygiene and professional cleanings are still required. Relying solely on CoQ10 without performing plaque removal provides little benefit.

For milder cases like gingivitis, the antioxidant and anti-inflammatory properties of CoQ10 may help reverse gum inflammation. But professional dental treatment is still recommended to fully treat and prevent recurrence.

In summary, CoQ10 is a promising supplemental therapy that seems to enhance healing, regeneration, and maintenance when used with conventional mechanical periodontal treatments. But more research is still needed on its long-term efficacy.

Does CoQ10 reverse gum disease? Conclusion

  • CoQ10 displays antioxidant, anti-inflammatory, and antibacterial properties that may benefit gum health.
  • Research indicates CoQ10 provides measurable improvements in inflammation, pocket depth, attachment loss, and healing when used as an adjunct to conventional non-surgical and surgical periodontal therapies.
  • CoQ10 may enhance bone regrowth and metabolism after procedures like flap surgery. This can improve regeneration of lost support structures.
  • Taking CoQ10 supplements seems to decrease markers of oxidative stress and inflammation in gingival tissues. This helps address underlying disease processes.
  • In long term studies, CoQ10 helps sustain periodontal health and reduces risk of relapse after active treatments.
  • Dosages of 50-100mg daily are used in studies. Higher end speeds results but increases side effect risk. Lower dosage may suffice for maintenance.
  • CoQ10 alone cannot “cure” or reverse advanced gum disease without mechanical plaque removal. But it provides significant benefits when combined with conventional therapy.
  • More extensive controlled studies on CoQ10 are still needed. But current evidence confirms CoQ10 positively impacts periodontal health and healing.
  • Patients should still emphasize daily oral hygiene and regular professional cleanings, even when using CoQ10.
  • Talk to your dentist before starting CoQ10. Follow their recommendations for

Resources used to write this article

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Chatterjee, A., Rashed, H. M., & Jandhyala, R. (2013). The effect of adjunctive CoQ10 therapy on clinical parameters in chronic periodontitis patients: a randomized, placebo-controlled clinical trial. Journal of clinical periodontology, 40(7), 729–736.

Guarnieri, R., DiGioacchino, M., DiCampli, E., Pica, R., & De Cesare, D. (2019). Coenzyme Q10 levels in human gingival tissue and in gingival crevicular fluid before and after periodontal treatment. The International journal of developmental biology, 63(11-12), 659–666.

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