Does CoQ10 make you stronger?


Coenzyme Q10, also known as CoQ10, is a vitamin-like substance that is produced naturally in the body. It plays an essential role in energy production and acts as a powerful antioxidant. In recent years, CoQ10 supplements have become increasingly popular due to their potential health benefits. But can CoQ10 make you stronger? Let's take a closer look at the evidence.

Can the antioxidant CoQ10 really boost strength? Learn what science says about the potential ergogenic benefits of CoQ10 supplementation.

What is CoQ10?

CoQ10 is a compound that helps generate energy in your cells. It's involved in making adenosine triphosphate (ATP), which serves as the cell's main energy source. CoQ10 exists in every cell of your body, but especially in organs with high energy demands like your heart, kidneys, and liver.

Some CoQ10 is produced naturally in the body, while we also get small amounts from food. Meat and fish are good sources of CoQ10. However, levels decrease as we age. This decline has been associated with various age-related conditions.

CoQ10 supplements may help raise CoQ10 levels. But does taking a CoQ10 supplement make you stronger? Here’s what science says so far.

How CoQ10 May Increase Strength

Research indicates that CoQ10 may improve strength through a few key mechanisms:

Improved Energy Production

By supporting ATP synthesis, CoQ10 is essential for energy production. It helps supply cells with the energy they need for muscle contraction. Low CoQ10 levels are linked to reduced ATP energy in muscle tissues.

Supplementing with CoQ10 may enhance energy production in muscle cells. This heightened muscular power output can translate to greater strength capacity.

Reduced Oxidative Stress

CoQ10 is a powerful antioxidant that fights oxidative stress in cells. Oxidative stress refers to an imbalance between free radicals and antioxidants in the body. The excessive buildup of free radicals from metabolism and intense exercise can impair muscle recovery.

CoQ10 helps neutralize these damaging free radicals. This may reduce oxidative damage to muscle fibers caused by intense training and exercise. Minimizing oxidative stress helps muscles recover faster for subsequent sessions.

Enhanced Mitochondrial Function

Mitochondria produce ATP energy in cells. CoQ10 is highly concentrated in mitochondria where it supports energy metabolism.

Research shows that when CoQ10 levels are low, mitochondrial function is impaired. This negatively affects muscle performance. Supplementing with CoQ10 appears to boost mitochondrial oxidative capacity, enhancing energy generation.

By improving mitochondrial efficiency, CoQ10 helps delay muscle fatigue so you can train harder for longer.

Anti-Inflammatory Effects

Strenuous exercise often provokes an inflammatory response in the body. While acute inflammation is a normal part of muscle repair and growth, excessive or prolonged inflammation interferes with recovery.

Some research indicates that CoQ10 exerts anti-inflammatory effects by reducing pro-inflammatory cytokines. Limiting exercise-induced inflammation may allow for faster repair between training sessions.

Does Research Show CoQ10 Supplementation Increases Strength?

While CoQ10 supplementation makes theoretical sense for improving strength, what does the research say?

Unfortunately, there are not many controlled studies examining CoQ10's effects on physical performance in young, healthy individuals. But a few reports suggest supplementation may enhance strength:

  • A 2015 study tested a combination of CoQ10 and other antioxidants in 20 elite soccer players. After 30 days, there were significant improvements in power output.
  • In a 2013 study, 18 male amateur boxers took CoQ10 or placebo daily while training for 7 weeks. The CoQ10 group saw lower lactate levels and heart rate during exercise, indicating less fatigue.
  • A small 2010 study found that 2 weeks of CoQ10 supplementation lessened muscle damage and soreness following repeated sprints in young active men.
  • Older adults with CoQ10 deficiency saw improved physical performance after supplementation, including increased power output during bouts of peak muscle exertion.

While promising, these studies are limited by their small sample sizes. Larger, longer-term studies are needed to confirm whether CoQ10 directly increases muscle strength. But the current evidence suggests it may offer performance-enhancing effects for some individuals.

CoQ10 Dosage for Strength Gains

There is no universally accepted dosage for CoQ10 and strength training. However, most studies use dosages between 100mg to 300mg per day. People already deficient in CoQ10 may see benefits from doses at the lower end of this range.

Some research suggests dividing the daily dose into smaller doses throughout the day could enhance absorption. For instance, 100mg taken 3 times a day.

Timing doses around exercise may also help. Taking CoQ10 about an hour before strength training allows levels to peak in your blood when you need it most. However, optimal timing and dosing frequencies require more research.

As with any supplement, it’s recommended to start low and slowly increase your dosage while monitoring effects and side effects. Work closely with your healthcare provider to find the most appropriate CoQ10 protocol.

Other Potential Performance Benefits

In addition to potentially increasing muscle strength, emerging research suggests CoQ10 offers other physical performance advantages:

  • Enhanced exercise tolerance - Lasting longer before reaching exhaustion during aerobic and anaerobic exercise.
  • Reduced perceived exertion - Feeling like you have to put out less effort during exercise.
  • Faster heart rate recovery - Return to normal heart rate is quicker after intense training.
  • Improved breathing efficiency - Respiratory exchange ratio is higher, indicating better oxygen use.
  • Increased fat oxidation - More fat is burned for fuel, conserving glycogen stores.
  • Lower blood lactate - Reduced lactate accumulation may delay onset of fatigue.
  • Greater muscle oxygen saturation - More oxygen delivered to working muscles.
  • Enhanced post-exercise recovery - Quicker recovery between training sessions.

While more research is warranted, these markers indicate CoQ10 may aid performance across various sports and types of athletic training.

Is CoQ10 Safe?

In healthy adults, CoQ10 is considered very safe, even at high doses. The most commonly reported side effects are stomach upset, loss of appetite, nausea, vomiting, and diarrhea. Fortunately, these mild GI issues typically resolve with continued use.

Rarely, CoQ10 may cause headaches or insomnia in sensitive individuals. It’s also important to note that CoQ10 may interact with blood-thinning medications like warfarin.

Overall, there is no strong evidence of serious adverse effects. However, there are some safety considerations:

  • Speak with your doctor before taking CoQ10 if you’re pregnant or breastfeeding, or if you have liver disease, diabetes, or other medical conditions.
  • Watch out for CoQ10 supplements that also contain vitamins A, E, K which may require medical monitoring.
  • Stick to reputable brands that adhere to good manufacturing practices (GMPs).
  • Start with low doses and increase slowly to gauge tolerance.
  • Take with food to minimize potential stomach upset.

With responsible use, CoQ10 is considered very low risk for healthy adults looking to enhance performance. But check with your healthcare provider if you have any concerns.


CoQ10 is an essential nutrient that supports cellular energy production and protects cells from oxidative damage. By improving energy generation in muscle tissues, CoQ10 supplementation may enhance strength capacity and physical performance.

Preliminary research shows some promising strength-boosting effects of CoQ10 in athletes and older adults. However, current evidence remains limited. Larger, more robust studies are still needed.

CoQ10 dosages between 100-300mg per day appear safe and well-tolerated for short-term use. But work with your doctor or dietitian to find the right protocol.

While more research is required, CoQ10 is emerging as a safe supplement that may provide an ergogenic edge for muscle power output. If you’re looking for a natural performance enhancer, CoQ10 is worth considering. But results will likely vary between individuals.

Does CoQ10 make you stronger? Conclusion

In summary, the evidence suggests CoQ10 may offer potential strength and performance benefits through its roles in energy production, antioxidant activity, inflammation reduction, and mitochondrial function. However, current research is limited and more studies are needed in young, healthy populations.

CoQ10 dosages from 100-300mg per day seem reasonably safe for short-term supplementation. But it's best to consult a healthcare practitioner to determine if CoQ10 is appropriate for your individual needs. While CoQ10 shows promise for sports applications, stronger data is still needed to conclusively state that CoQ10 definitively increases muscle strength and physical performance. More research in athletes and active individuals will help clarify if CoQ10 lives up to its potential as an ergogenic aid.

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