One of the widely available forms of CBD is crystals with 99% CBD purity. The crystalline CBD producers start from good plant material hemp extracts, just like we do. But their product differs from our golden oil as they deliberately remove all the other good compounds present in the extract. During their process, CBD crystal manufacturers lose the full cannabis phytocomplex - the other non-psychoactive cannabinoids such as CBG, CBC, and CBN as well as terpenoids and amino acids.
The rationale behind going through the stage of very pure CBD is old-fashioned. In recent history, people thought that the more of the active compound you use and the purer it is, the better. The other rationale being that you need to remove the THC for legal reasons, and the easiest way to do this is to work with CBD crystals.
But putting aside the legal reasons, we now know that maximum purity being the best is not true for all natural compounds. Think about pure, crystalline white cane sugar and less purified brown sugar. The white sugar delivers pure sucrose, but brown sugar has a better taste and more minerals because of the presence of additional compounds - molasses.
We do not get rid of the CBD-accompanying compounds such as terpenes and terpenoids from our Cibdol oil. On the contrary, we add the terpenes back to our pure oil with high content of CBD. Just like molasses in sugar, full spectrum terpenes and terpenoids that accompany cannabinoids confer better taste.
More importantly, having full phytocomplex provides additional health benefits. The synergy in CBD and terpenoids action is called entourage effect; the oils produced from CBD crystals lack it. CBD works better with the body when it has its natural accompaniment of compounds found in hemp, not as a pure isolate.
That is why we don’t use the crystals in our oil. We know that natural golden oil is superior. We do use the CBD crystals in the skin creams, because on the skin you want a quick absorption and no interference of other plant oils.
Israeli scientists have been on the forefront of cannabidiol research for many years, starting with the discovery of CBD by Raphael Mechoulam. The “father of cannabinoid research’’ also proposed the hypothesis of the entourage effect - that the full cannabis phytocomplex works better than each component in isolation.
In a recent scientific paper, the scientists working at the Hebrew University of Jerusalem investigated the anti-inflammatory and pain-relieving effects of full phytocomplex extract that included non-psychoactive cannabinoids and terpenes.
The scientists describe the “bell-shaped effect” of pure cannabinoid. The “bell-shaped” refers to the curve of the cannabinoids action. At a low dose of pure CBD, the anti-inflammatory and pain relieving effects increases as the dose increase. Then cannabinoids achieve the maximum effect in a narrow dose window. However, after the peak, the increase of the amount of CBD actually decreases its positive effects.
The Israeli scientists investigated the action of ethanol-extracted phytocomplex containing CBD, other cannabinoids and terpenes. Instead of a bell curve effect of the pure compounds, they discovered a linear rise and then flatlines - e.g. the organism reaction, in the beginning, was proportional to the dosage and then reached saturation. The researchers concluded, “It is likely that other components in the extract synergize with CBD to achieve the desired anti-inflammatory action that may contribute to overcoming the bell-shaped dose-response of purified CBD.”
According to this study, not only is having the full phytocomplex instead of using CBD crystals-derived oil more beneficial to the organism, but also other compounds naturally produced by cannabis enhance the cannabinoids action.